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Skin Barrier Calming Mask

Cytogen Masque

Regular price
$156.00
Regular price
Sale price
$156.00
Shipping calculated at checkout.
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Powered by CELLULAR INTEGRITY FACTOR™

CYTOGEN Masque is a restorative biocellulose mask infused with bovine milk secretome to help your skin recover from stress, aesthetic procedures, and environmental damage. Powered by CELLULAR INTEGRITY FACTOR™, a bio-signaling complex featuring actives such as cytokines and TGF-β, this advanced formula supports the skin’s natural healing process to calm inflammation, repair the barrier, and restore balance.

The biocellulose base fits like a second skin, allowing ingredients to absorb deeply for maximum results. With soothing Allantoin, barrier-strengthening Niacinamide, hydrating Betaine, and protective Ectoin and Resveratrol, this mask leaves skin visibly calmer, hydrated, and renewed after every use.

BENEFITS
  • Accelerates skin recovery and repair
  • Calms inflammation and redness
  • Strengthens the barrier against stressors
  • Deeply hydrates and restores balance
  • Ideal for post-procedure care or weekly renewal
INGREDIENTS

BOVINE MILK SECRETOME

Rich in cytokines and biosignaling peptides like TGF-β to activate repair and regeneration.

ALLANTOIN

Calms irritation and reduces sensitivity.

ECTOIN

Protects against oxidative and environmental stress.

NIACINAMIDE

Strengthens barrier function and refines skin texture.

ESCIN

Reduces redness and supports circulation.

Full Ingredient List
HOW TO USE

Apply to clean skin for 15+ minutes whenever your complexion needs recovery, after cosmetic procedures, periods of stress, or when the skin feels compromised.

For regular barrier support, use 1–3 times per week.

Cytogen Masque
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Cytogen Masque

Barrier Repair

Strengthens and heals the skin barrier to restore its natural defense mechanism.

Calming & Soothing

Reduces redness, irritation, and sensitivity, making it ideal for post-procedure skin.

Strengthens Skin Resilience

Protects the skin from future environmental damage while promoting healthy cell turnover.

Hydration Intelligence

Locks in moisture, leaving the skin feeling soft, plump, and rejuvenated.

Milk reimagined for your skin.

Before
After

Confident Results

Experience Visible Relief
  • Patients experience immediate relief and lasting comfort.
  • After just one application, skin appears calmer, more hydrated, and visibly renewed.
  • With continued use, barrier strength and resilience visibly improve.

Actual patient treated with a combination of Moxi® fractional laser and a 15-minute CYTOGEN Masque application.
Results shown immediately after use. Individual results may vary.

  • QuantifiCare Patient 1

  • QuantifiCare Patient 2

Actual patient treated with a combination therapy followed by a 15-minute CYTOGEN Masque application.

Results shown immediately after use. Individual results may vary.

SEE CLINICAL EVIDENCE

Actual patient treated with a combination therapy followed by a 15-minute CYTOGEN Masque application.

Results shown immediately after use. Individual results may vary.

SEE CLINICAL EVIDENCE
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Discover Your Benefits

Experience the Cytogen Masque difference

  • Biocellulose matrix mimics skin for deep absorption.
  • Medical-grade material used in post-procedure care.
  • Enriched with bioactive cytokines, ectoin & allantoin.
  • Inspired by skin regeneration, engineered for precision delivery.

How to Use Cytogen Masque

Open the sachet and unfold the mask. It’s wrapped in two protective layers to keep the delicate biocellulose drenched—and intact—until application.

  1. Peel off the non-woven organic film.
    Apply the exposed, smooth side of the mask to your face.
  2. Remove the second protective mesh.
    Smooth the biocellulose so it hugs every contour.
  3. Leave on 15 minutes. Do not rinse. Massage in any excess.
  4. Follow with your favorite serum and moisturizer as needed.

Routine: Use 1–3× weekly, or anytime skin feels stressed or depleted.

READ BEHIND THE SCENES

The Art of Repair Through Bovine Milk Secretome

LITERATURE REVIEW

Bovine Milk Secretome Simply

It’s the skin-friendly signals naturally found in cow’s milk - tiny messengers (like proteins and growth factors) that tell cells to calm down, hydrate, and repair.

Efficient Messengers

These signals nudge skin cells to help calm inflammation, repair the barrier, and balance how skin behaves (think: less redness, better resilience).

Pure and Effective

Purified into skincare to support post-procedure recovery, stressed/sensitive skin, and overall hydration/soothing.

Play Nice Active

Helps calm and rebuild - even on a compromised barrier. It pairs well with niacinamide, ectoin, ceramides, and many other actives.


Gentle, consistent use beats “overnight miracle.”

  • The Heart of Cytogen Masque

  • Biocellulose

  • Niacinamide

  • Allantoin

  • Ectoin

CYTOGEN Masque is powered by bioactive ingredients designed to work in sync with your skin. Each molecule is selected in its most effective form to support natural regeneration, calm inflammation, and strengthen the barrier, helping skin return to its healthiest, most resilient state.

READ BEHIND THE SCIENCE

Nanofiber hydrogel grown by beneficial bacteria. These are well tolerated by the skin, boost surface hydration, help maintain barrier integrity, and act as carriers for hydrophilic actives.

LEARN MORE

Strengthens barrier function and refines skin texture.

Calms irritation and reduces sensitivity.

Protects against oxidative and environmental stress.

FAQs

Do I need to have a cosmetic procedure to use CYTOGEN Masque?

Not at all. While CYTOGEN was designed with post-procedure recovery in mind, it’s equally effective for everyday barrier support, stressed skin, or whenever your complexion needs a reset.

Can I use CYTOGEN Masque after a cosmetic procedure?

Yes. CYTOGEN Masque was formulated to enhance post-procedure recovery. Its bio-signaling actives, cytokines, and soothing ingredients help calm inflammation, reduce redness, and support faster skin regeneration.

Is it suitable for sensitive skin?

Yes. CYTOGEN Masque was created for compromised and reactive skin types. The formula is free from irritants and includes ingredients like Allantoin, Ectoin, and Niacinamide to calm and comfort sensitive skin.

Does it contain alcohol or fragrance?

No. CYTOGEN Masque is alcohol-free and fragrance-free, making it safe for even the most delicate or reactive skin.

How often should I use it?

Use 1–3 times per week for 15+ minutes, or whenever your skin feels dry, inflamed, or stressed. After cosmetic procedures, use as recommended by your skincare professional to support healing.

Can I layer it with other products?

Yes. Apply CYTOGEN Masque on clean skin before your moisturizer or treatment products. It enhances absorption and recovery, making your routine more effective.

What does it feel like on the skin?

The biocellulose material adheres like a second skin - breathable yet deeply hydrating. It delivers actives evenly across the face for a cooling, calming, and restorative experience.

The Routine

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Start Fresh

Begin your routine with a gentle cleanse to remove makeup, dirt, and oil. This essential first step creates the perfect canvas for the products that follow.

Gentle Barrier Reset

Apply your treatment mask to address specific skin concerns. This intensive step delivers powerful ingredients deep into the skin for transformative results.

Double Repair

Apply serums and treatments to target your specific skin concerns. These concentrated formulas work at the epidermis to deliver visible results.

Hydrate Intelligently

Seal with moisturizer to lock in all the benefits of your routine. This step creates a veil to keep your skin hydrated throughout the day.

Seal & Protect

Finish your routine with SPF to lock in glow and defend against UV damage.

  • 5 stars: 42 (84%)
  • 4 stars: 7 (14%)
  • 3 stars: 1 (2%)
  • 2 stars: 0 (0%)
  • 1 star: 0 (0%)
T
Terrie Griggs
A must-have for dry, thirsty skin!

"I have always had very dry skin, and the Bionassay Cytogen Masque has honestly been a game changer for me! From the first use, my skin felt deeply hydrated, soft, and noticeably more plump. The biocelluose material fits like a second skin. So. it really locks in all the nourishing ingredients without sliding around or drying out.
After using it consistently, I’ve seen a big improvement in dryness and tightness - especially around my cheeks where I struggle the most. My skin looks smoother, feels calmer, and has that healthy glow that’s hard to get with dry skin! It’s rich and soothing but doesn’t leave behind any sticky residue.

If you struggle with dry skin and needs something that truly restores moisture and supports your skin barrier, this mask is absolutely worth trying!"

s
shannon_watson
Post treatment heaven

"This is not your every day sheet mask.

It is loaded with a creamy essence and fits like a second skin.

It’s the ingredients that make it different though, designed to help skin recover from stresses like deeper treatments, this soothes and helps heal the skin

Using it was beyond enjoyable. The packaging is well thought out, and feels luxurious. There was no noticeable scent, once applied it stayed in place perfectly until I removed it after 20 minutes.

My skin felt hydrated, soothed, and plump. While I had not had any recent stressors to speak to the recovery benefit, I do think based on what’s in it, and how my skin responded I would grab these to have on hand if I were to need them.

The price is hefty, but like I said, this isn’t your standard any day sheet mask, this would be for specific occasions."

G
Gracie S
Very calming and hydrating

This is the best mask I have ever tried. It has a nice, rich cream, and the texture of the mask is jelly-like. I left it on for 15 minutes, and when I took it off, my face felt so hydrated and refreshed. I will definitely reach for these masks when my skin barrier is irritated.

A
Amanda Sutton
Relaxing and hydrating

I really enjoyed this mask! It clung to my skin beautifully, making for an easy and comfortable application. My skin felt very plump and hydrated after wearing it just once, and I love the way my skin looks afterward too. It was gentle enough for my skin and had no scent at all, which I appreciate.

C
Courtlandt
Great for stressed and damaged skin barrier!

These Bionassay Cytogen masques were so luxurious. My skin has been stressed, and my barrier has needed repair after using the wrong actives in my skincare routine. I could feel this mask tingling and helping to soothe my skin barrier. Afterward, my skin was glowing and hydrated, and it was quick and easy to remove. It’s great that this product comes in a 5-pack, so you can continue the treatment several times if you really need barrier support or want to soothe stressed skin after sun damage, irritation, or overdoing actives. I really liked this mask!

J
Jess
A new staple

I tried the Bionassay Cytogen Masque and loved it. It made my skin feel super smooth and soft, and it absorbed really fast. I even wore it while picking up my kids from school — they thought it was hilarious, but my skin felt amazing afterward!

a
alexandras4_3747
The sheet mask for rich folks

"$157 for a sheet mask set is a tough sell. Let’s talk about it.

This mask is nice, I’ll give you that. There is a lot of leftover serum that you can use for days with proper storage. Where I struggled was with the application. I found it a little odd because the pieces come apart, and it is unclear which side you should put on your face. I winged it. The positives are that the ingredients feel very premium.

I think I’d prefer this in an actual serum because the application wasn’t my favorite, but the quality stands out. If this fits comfortably into your skincare budget, it’s probably a winner."

j
josie_morrow
Wonderful nourishment and healing! ✨💖

"I absolutely loved these masks! They have no overpowering scent and don’t leave a sticky residue, which I really appreciate. They left my skin feeling incredibly smooth, refreshed, hydrated, and soothed. After using them, my face looked healthier and felt more nourished.

One tip for first-time users: the mask has a protective layer that needs to be removed before applying. I didn’t realize this with my first one, so it felt heavier and didn’t stick as well. Once I removed the extra layer on my second use, it fit much better and stayed in place perfectly.

Overall, these masks are amazing for hydration and skin comfort. I will definitely recommend them and continue to use them!"

M
Marlene J
Refreshes and Soothes Skin

This mask has so much product on it, which makes it very easy to use. It feels refreshing while it’s on. The fit is a bit big, but that doesn’t bother me at all. It has a great consistency, and my skin absorbs it so well. After removing it, my skin feels much better and softer. I put the excess on my neck and ears as well, and they feel so good. My face felt great during the day and even through the night.

B
Brandy
Super moisturizing

I was super excited to get this mask because I have heard such great things! I wasn’t disappointed. The only thing I would change is the eye holes. I had to put the flaps in so it wasn’t all weird outside

Thank you so much for sharing this thoughtful feedback — we’re really happy to hear how well the mask is soothing, hydrating, and calming your skin

Just a quick note on the biocellulose fit: from the picture, it looks like the two protective layers weren’t fully removed. Those layers are there to keep the biocellulose intact, but once both are peeled off, the mask becomes much more flexible and should contour seamlessly to the face. Without them, it typically adheres very closely, even around more delicate areas.

We truly appreciate you taking the time to share your experience, and we’re so glad the results still made it worth it for you. Thank you again!

V
Valentina Figgins
Easy application and feels great.

This mask feels fantastic on my face and has a nice cooling feeling. My face looks and feels smoother after application. The scent was pleasant, and the packaging is very classy. For the look and feel of this mask, I believe it provides tremendous value.

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cre8ivillusn_93
Amazing and by far the best!!

Alright,  this is AMAZING! By far the BEST mask I have ever used. I do have sensitive skin and this dodnt irritate my skin at all. There are little flaps under the eyes that you have to tuck in before smoothing it around your face. Don't forget that step, and dont tear them off. I left this on for the alloted time. Took a before and after photo/video. In the 15 mins I had this on, it brightened my skin and smoothed it out. Took away the redness, once the lotion from thr mask dried.  No irritation whatsoever.  Left my skin soft, bright and youthful looking. Even my husband noticed the difference in 15 mins!!!

M
Minh D
“emergency" treatment of stressed skin.

I had two large, inflamed pimples (one on my temple and one on my cheek), the one on my cheek was a cystic acne. My skin is very sensitive, so I'm always skeptical about products. I used it last night and woke up this morning to find those pimples completely gone and no longer red. I didn't use any other products besides applying the mask for 20 minutes (as directed) after my two-step cleansing routine. It has a light texture, absorbs easily, and I could immediately notice a reduction in redness and irritation. This product is perfect after a long day or as a quick treatment to help restore stressed skin. While wearing the mask, my skin didn't feel any stinging. The next morning, my face felt plumper. What I liked most about this mask is its ability to deeply moisturize without feeling heavy or sticky. The soothing effect lasted a long time after removing the mask, and my skin felt soft and refreshed. This product quickly became an indispensable part of my skincare routine. I would definitely recommend it to everyone.

T
Toho A
Deeply hydrating and calming

I really love this mask overall. The essence is very generous, creamy, and feels instantly cool and soothing on my skin. It provides deep hydration and nourishment, helping my skin feel calm, well-moisturized, and refreshed after each use. I leave it on for about 15 minutes, and every time my skin looks softer, more balanced, and less irritated. The only small downside is the biocellulose base, it feels a bit stiff, and even after gently smoothing it out, the mask doesn’t fully adhere to every area of my face. That’s the one thing I don’t love, but the results still make it worth using.

Thank you so much for sharing this thoughtful feedback — we’re really happy to hear how well the mask is soothing, hydrating, and calming your skin

Just a quick note on the biocellulose fit: from the picture, it looks like the two protective layers weren’t fully removed. Those layers are there to keep the biocellulose intact, but once both are peeled off, the mask becomes much more flexible and should contour seamlessly to the face. Without them, it typically adheres very closely, even around more delicate areas.

We truly appreciate you taking the time to share your experience, and we’re so glad the results still made it worth it for you. Thank you again!

V
Viola L
Next level drunk for your skin!

This is the only mask I've ever used like this and I think it's the best mask has milk in it. My skin drank this like it was empty and she was thirsty. It feels super luxe there's so much serum left in it so much milk kind of no sense scent kind of product. The packaging is very lux and it's instant when it's working. You can definitely feel it hugging the upper layers of your skin. I would recommend this for anybody on any type of skin type especially if you're having breakouts or eruptions or just sensitivity it would definitely calm it down!!

s
soyminniee_1193
Glow 🔆

I absolutely loved this mask! The biocellulose material feels very high-quality and adheres perfectly to the skin, almost like a second skin. It stays in place the entire time and feels incredibly soothing and refreshing.

After using it, my skin looked noticeably more hydrated and radiant. It gave me that healthy glow without feeling sticky or heavy. My skin felt smoother and calmer, especially after a long day.

I also appreciated how luxurious the experience felt — from the packaging to the results. This mask is perfect before a special event or whenever your skin needs an extra boost of hydration and care.

I would definitely repurchase and recommend it to anyone looking for an instant glow and deep hydration! ✨💆🏽‍♀️

A
Angel Heath
Hydrating, smoothing and soothing

Oh my GOSH this initially sounds very expensive but as a skin care fanatic this is worth every single penny. When you first open the face mask it’s sandwiched between 2 mesh like pieces of material and is super foamy looking. You remove the mesh like material and put the face mask on and it just instantly absorbs into your skin. I have chronic dry skin and just one face mask feels like my skin has transformed and I’m not exaggerating. I will absolutely be purchasing these in the future when I run out. I noticed no scent at all, experienced no breakouts after use and I used the extra serum around my lips where the mask didn’t quite touch for a bonus serum. I seriously loved this mask and the quality is clear. 10/10 would absolutely buy these again and again.

v
valerie_bw
The best facial mask in my life

I can honestly say this is the best face mask I have ever tried in my life. It’s not just good- it’s truly exceptional.

First of all, the mask is so heavily saturated with serum. There is a lot of product, and you can really feel that they didn’t hold back at all. The mask is drenched in a rich emulsion, and it feels incredibly luxurious on the skin.

It also stays on the face perfectly. It feels like it’s glued on, so you can move around and do your things without worrying that it will slip off. That’s something I really appreciated.

The moment I put the mask on, I immediately felt this amazing sensation of freshness and lightness. It was so soothing and cooling, like my skin instantly relaxed.

After about 15–20 minutes, when I removed it, I was honestly shocked by the results. The freshness effect was unbelievable — it felt like I was given a brand new layer of skin. My skin looked super hydrated, even though that day it was dry and windburned from the cold weather. It also felt tightened, refreshed, and visibly rejuvenated.

I don’t even know how else to describe this feeling it was like my skin had been completely revived. There are many great face masks out there, but this one is hands down the best.

V
Valerie Smith
This mask is incredible

This mask is incredible, once I figured out how to put it on I didn't take it off for an hour!

R
Raphael de Haussy
Best facial serum, even after shaving

Best facial serum, even after shaving.

E
Eli Mauras
Savior for rosacea flareups

I have rosacea and my cheeks get red so easily, especially after a shower, being outside in the heat, or using the wrong product. I’m always nervous with masks because a lot of them feel nice at first but end up making my skin more irritated. This one felt cooling right away and didn’t sting at all. I left it on while my skin was feeling really flushed, and when I took it off, my face looked calmer and less blotchy. It didn’t completely erase the redness, but it definitely helped bring it down and made my skin feel more comfortable. I’ve been using it whenever I feel a flare-up coming on or when my skin just feels hot and reactive. It feels like a safe little reset for sensitive skin.

M
M. Sandoval
Acne and redness

I struggle with breakouts, but the redness afterward is usually what bothers me the most. I use this when my skin is feeling irritated from acne products, and it really helps calm everything down. It doesn’t make me oily, or clog my pores, and doesn’t make my active breakouts worse. My skin also feels less tight after. I’ll definitely keep using it when my skin is acting up.