Why biocellulose is the right delivery system for CYTOGEN Masque

Why biocellulose is the right delivery system for CYTOGEN Masque

Why biocellulose is the right delivery system for CYTOGEN Masque


Biocellulose is a nanofiber hydrogel grown by beneficial bacteria. It first earned its stripes in wound care because it is pure, biocompatible, highly water‑holding, breathable, and conformable. Those same traits make it an outstanding cosmetic sheet‑mask substrate. Clinical and materials studies show biocellulose masks are well tolerated, boost surface hydration, help maintain barrier integrity, and carry hydrophilic actives—including in post‑procedure settings where skin benefits from cooling comfort.
CYTOGEN Masque pairs biocellulose with a milk‑derived secretome (tiny “message” molecules). On receptive skin, these messages help cue the skin’s own surface‑level signaling, so your skin can do its job better—no needles, no drama.

 

What is biocellulose?

Biocellulose (often called bacterial cellulose) is a web of ultrafine cellulose fibers. 

Think of biocellulose as a silky, water‑rich mesh made of nanosized fibers. It’s grown in water by friendly bacteria, then purified and formed into a thin sheet.
Because the fibers are so fine and tightly woven, the sheet can soak up ~100–200× its dry weight in water and cling to your face comfortably—like a soft, breathable second skin.

What was it made for originally?

Not from the beauty aisle. Doctors used it first for burns and delicate wounds because it keeps skin moist, lets air through, eases discomfort, and stays put. That medical‑grade comfort is exactly why premium sheet masks switched to biocellulose.

How does a biocellulose mask work on your face?

  1. The sheet is pre‑soaked with serum (the good stuff).

  2. You apply it and it hugs every curve—cheeks, nose, chin.

  3. That close contact creates gentle occlusion (a light seal), which slows water from evaporating and gives your skin time to drink.

  4. While you wear it, the mask steadily releases the watery ingredients onto the outer layer of your skin.

What results can you expect?

  • Quick, visible hydration. Skin looks plumper and fresher because it’s holding more water.

  • Comfort. It feels cooling—great when skin is tired, stressed, or after a pro treatment (if your provider approves).

  • Even delivery. Because it fits so well, you don’t get “dry corners” or “wet patches.”

  • Gentle on most skin. It was born in medicine, so it’s designed to be calm and breathable.

(Reminder: this is cosmetic care—think comfort and appearance, not medical treatment.)

What does the evidence say?

  • Hydration & tolerance: Human studies show better skin hydration, texture, and elasticity over several weeks, with good tolerability and no harm to the skin barrier on standard tests.

  • Post‑procedure comfort: In split‑face clinical trials after microneedling or laser, biocellulose masks reduced heat and discomfort and were well tolerated (use only per your provider’s advice).

  • Delivery of actives: Lab and product studies show biocellulose can hold and steadily release water‑loving ingredients (think caffeine or antioxidants) rather than just acting like a wet cloth.

Why pair biocellulose with the CYTOGEN milk secretome?

The milk secretome is a mix of tiny “message” molecules—like friendly notes for your skin.

  • Your skin cells have little doorbells on their surface (receptors).

  • When the right “message” touches the doorbell, the cell notices and responds, starting a normal, surface‑level care‑and‑repair chain reaction.

  • Biocellulose makes skin more receptive by hydrating and gently sealing the surface, so those messages are more likely to be noticed.

Bottom line: CYTOGEN Serum + biocellulose = comfy contact time + hydrated, receptive skin, so your skin can respond to the message.

Note: Effects are surface‑level and supportive. On intact skin, bigger molecules (like proteins and vesicles) mostly stay near the surface. The masque’s value is creating the right micro‑environment—hydrated, close contact—so the epidermis can do its job. In clinic‑guided settings that create temporary micro‑channels (e.g., microneedling), your provider may advise different usage.

How to use CYTOGEN Masque

  1. Cleanse and pat dry.

  2. Apply the mask and smooth it down so it touches everywhere.

  3. Relax for 15–30 minutes.

  4. Remove and press in the leftover serum on your face, neck, and hands.

  5. Seal with your moisturizer (and sunscreen in the morning).

How often: 1–3 times a week. If you’ve had a procedure, follow your provider’s advice.

Benefits at a glance

  • Deep, lasting hydration — helps skin hold onto water.

  • Comfy and cooling — feels great when skin is hot, tight, or tired.

  • Snug fit = even results — no slipping, no dry‑out.

  • Great with watery actives — holds and releases them right where you need them.

  • Naturally clean — made without plant “extras” like lignin, and the sheet is biodegradable.

FAQs

Will it clog my skin?
Unlikely. The sheet is breathable and the finish is lightweight. Always listen to your skin and routine.

Can I use it after microneedling/laser?
Only if your professional says so. Biocellulose is known for comfort, but post‑procedure care should follow your provider’s plan.

Is it good for sensitive skin?
Many people find biocellulose very gentle because of its medical roots. If you’re reactive, do a short patch test first.

The rise of biocellulose from medical wound dressings to modern skincare is more than a beauty trend — it’s true technology transfer. Over the past decade, biomedical research has celebrated biocellulose for its biocompatibility, breathability, water retention, and adaptability in applications ranging from wound care to tissue scaffolds and drug-delivery systems. Those same qualities now redefine the skincare experience, delivering comfort, deep hydration, and controlled ingredient release through a sheet mask that feels like a natural extension of the skin itself.

If your skin craves instant hydration, soothing comfort, and a smarter way to keep active ingredients where they belong, biocellulose is the gold standard. That’s why Bionassay built CYTOGEN Masque on this material — a soft, second-skin veil that allows your skin to absorb what it needs, respond naturally, and emerge refreshed — all in one effortless step.

Glossary

Epidermal receptors

The skin‑cell doorbells that notice helpful messages.
When the right ingredient touches these doorbells (receptors), the cell “gets the message” and starts a response.

Biosignaling

The chain reaction after a doorbell is pressed.
It lets cells talk to each other and coordinate results—like nudging fibroblasts, supporting collagen upkeep, and balancing inflammatory signals (often seen as less visible redness and discomfort).

Vesicles / Extracellular vesicles (EVs)

Little message bubbles cells use to talk to each other.
They’re part of the secretome and are expelled by cells (common types include exosomes and microvesicles). In skincare, they mostly act on or near the surface of intact skin.

Keratinocytes

The main skin cells in your outer layer—the “brick‑layers” of your skin barrier.
They don’t just build the wall; they also listen for messages and send messages to other cells.

Signal‑sensing cells

Cells that notice a message and respond.
At the surface, keratinocytes are the stars. They then “text” deeper cells such as fibroblasts (collagen builders), immune cells (calm/defend), melanocytes (pigment control), and endothelial cells (tiny blood vessels).

Secretome

A cell’s “message mix.”
It’s the soup of signals cells release—proteins, peptides, lipids, and extracellular vesicles—that nearby cells can detect.


Friendly note: This is cosmetic care. It doesn’t diagnose, treat, or cure conditions. For procedure‑specific advice, follow your clinician’s instructions.

References
  • Amnuaikit, T., Chusuit, T., Raknam, P., & Boonme, P. (2011). Moisturizing effects of a cellulose mask synthesized by a bacterium. Medical Devices: Evidence and Research, 4, 77–83. https://doi.org/10.2147/mder.s20935
  • Bilgi, E., Homan Gokce, E., Bayir, E., & Altinsoy, B. (2021). Bacterial cellulose-based facial mask with antioxidant property and high moisturizing capacity. Cellulose, 28, 10399–10414. https://doi.org/10.1007/s10570-021-04106-z
  • Gorgieva, S., & Trček, J. (2019). Bacterial cellulose: Production, modification and perspectives in biomedical applications. Nanomaterials, 9(10), 1352. https://doi.org/10.3390/nano9101352
  • Horue, M., Silva, J. M., Berti, I. R., Brandão, L. R., Barud, H. d. S., & Castro, G. R. (2023). Bacterial cellulose-based materials as dressings for wound healing. Pharmaceutics, 15(2), 424. https://doi.org/10.3390/pharmaceutics15020424
  • Perugini, P., Bleve, M., Colombo, M., & Cervellati, F. (2018). Biocellulose masks as delivery systems: A novel methodological approach to assure quality and safety. Cosmetics, 5(4), 66. https://doi.org/10.3390/cosmetics5040066
  • Perugini, P., Colombo, M., & Cervellati, F. (2019). In-vivo evaluation of the effectiveness of biocellulose facial masks. Journal of Cosmetic Dermatology, 18(6), 1815–1822. https://doi.org/10.1111/jocd.13051
  • Silva, N. H. C. S., Ferreira, M. S. G., Vilela, C., Freire, C. S. R., Gomes, P., & Silvestre, A. J. D. (2014). Topical caffeine delivery using biocellulose membranes. Cellulose, 21(3), 1271–1280. https://doi.org/10.1007/s10570-013-0114-1
  • Siperstein, R., et al. (2024). Randomized split-face study using a post-procedural biotech cellulose mask for patient comfort and downtime reduction. Journal of Cosmetic Dermatology. https://doi.org/10.1111/jocd.16241
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